Violacein extracted from Chromobacterium violaceum inhibits Plasmodium growth in vitro and in vivo.
نویسندگان
چکیده
Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
منابع مشابه
Chromobacterium violaceum: a review of pharmacological and industiral perspectives.
Violet-pigmented bacteria, which have been described since the end of the 19th century, are occasionally the causative agent of septicemia and sometimes cause fatal infection in human and animals. Bacteria, producing violet colonies due to the production of a nondiffusible pigment violacein, were classified as a redefined genus Chromobacterium. Chromobacterium violaceum is gram-negative, and sa...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 53 5 شماره
صفحات -
تاریخ انتشار 2009